APPENDIX 11 - HETEROGENEITY TEST CALCULATIONS

Table A6. Heterogeneity Test for others' alcoholic populations.


Paper              A1A1      A1A2     A2A2     Total     chi2    

                                                                

Blum et al,          1        13       8        22      5.884   
1990                                                            

                   0.613    7.851    13.535                     

                                                                

Bolos et al,         3        12       25       40      3.554   
1990                                                            

                   1.115    14.275   24.610                     

                                                                

Blum et al,          3        39       47       89      2.856   
1991                                                            

                   2.481    31.762   54.757                     

                                                                

Comings et al,       3        41       60       104     0.658   
1991                                                            

                   2.900    37.115   63.985                     

                                                                

Gelernter et         1        18       25       44      0.536   
al, 1991                                                        

                   1.227    15.703   27.071                     

                                                                

Parsian et al,       0        13       19       32      1.135   
1991b                                                           

                   0.892    11.420   19.688                     

                                                                

Schwab et al,        0        11       34       45      4.289   
1991                                                            

                   1.255    16.059   27.686                     

                                                                

Cook et al,          1        4        15       20      2.320   
1992                                                            

                   0.558    7.138    12.305                     

                                                                

Goldman et al,       0        14       32       46      2.122   
1992                                                            

                   1.283    16.416   28.301                     

                                                                

Turner et al,        0        9        38       47      7.766   
1992                                                            

                   1.310    16.773   28.916                     

                                                                

Amadeo et al,        3        18       28       49      2.122   
1993                                                            

                   1.366    17.487   30.147                     

                                                                

TOTAL               15       192      331       538     33.243  


For each phenotype, the observed number is shown above, with the expected number shown below. The chi-2 value for each row is also shown, along with the total chi-2 for the table. The degrees of freedom is the number of rows minus one times the number of columns minus one, in this case, df=(11-1)(3-1), or 20.

Table A7. Heterogeneity Test for others' control populations


Paper              A1A1      A1A2     A2A2     Total     chi2    

                                                                

Blum et al,          0        4        20        24     1.646   
1990                                                            

                   0.915    5.488    17.597                     

                                                                

Bolos et al,         8        30       89       127     2.276   
1990                                                            

                   4.840    29.042   93.118                     

                                                                

Blum et al,          0        6        25        31     1.576   
1991                                                            

                   1.181    7.089    22.730                     

                                                                

Comings et al,       0        24       84       108     4.428   
1991                                                            

                   4.116    24.697   79.187                     

                                                                

Gelernter et         3        21       44        68     2.663   
al, 1991                                                        

                   2.592    15.550   49.858                     

                                                                

Parsian et al,       0        3        22        25     2.979   
1991b                                                           

                   0.953    5.717    18.330                     

                                                                

Schwab et al,        8        14       47        69     11.422  
1991                                                            

                   2.630    15.779   50.592                     

                                                                

Cook et al,          0        6        14        20     1.237   
1992                                                            

                   0.762    4.574    14.664                     

                                                                

Goldman et al,       2        11       23        36     1.655   
1992                                                            

                   1.372    8.232    26.396                     

                                                                

Amadeo et al,        0        7        36        43     3.089   
1993                                                            

                   1.639    9.833    31.528                     

                                                                

Total               21       126       404      551     32.972  


For each phenotype, the observed number is shown above, with the expected number shown below. The chi-2 value for each row is also shown, along with the total chi-2 for the table. The degrees of freedom is the number of rows minus one times the number of columns minus one, in this case, df=(10-1)(3-1), or 18.